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M94A0298.TXT
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1994-10-08
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Document 0298
DOCN M94A0298
TI [Sputum examination in the diagnosis of Pneumocystis carinii pneumonia
in HIV-infected patients]
DT 9412
AU Schlatter CE; Kuster H; Luthy R; Weber R; Russi EW; Opravil M;
Departement Innere Medizin, Universitatsspital Zurich.
SO Dtsch Med Wochenschr. 1994 Aug 26;119(34-35):1151-5. Unique Identifier :
AIDSLINE MED/94357054
AB To assess the sensitivity and negative predictive value of sputum
examination for Pneumocystis carinii in HIV-positive patients,
follow-ups were performed in HIV-infected patients who had been
investigated for the presence of Pneumocystis carinii (376 examinations
of sputum and 71 bronchoalveolar lavages). Pneumocystis carinii
pneumonia was diagnosed 65 times in 64 patients (57 male and 7 female,
median age 35 [23-67]years). In 52% of the cases (n = 34) the pathogen
was identified in the sputum, in 48% (n = 31) by means of the
bronchoalveolar lavage. Of 342 negative findings in sputum examination,
five were definitely false negative since the subsequent lavage yielded
pneumocysts. In nine further cases Pneumocystis carinii pneumonia could
not be excluded because of the course of the disease. In patients from
whom sputum samples were available the sensitivity of pathogen
identification was at least 70.8% and the negative predictive value at
least 95.9%. Since preceding prophylaxis did not render identification
in the sputum more difficult, examination of spontaneous or provoked
sputum is indicated as a first hand measure in all patients infected
with HIV in whom Pneumocystis carinii pneumonia is suspected.
DE Adult Aged AIDS-Related Opportunistic
Infections/*DIAGNOSIS/EPIDEMIOLOGY Bronchoalveolar Lavage
Fluid/MICROBIOLOGY Chi-Square Distribution English Abstract False
Negative Reactions Female Follow-Up Studies Human HIV
Infections/*COMPLICATIONS/EPIDEMIOLOGY *HIV-1 Male Middle Age
Pneumocystis carinii/*ISOLATION & PURIF Pneumonia, Pneumocystis
carinii/*DIAGNOSIS/EPIDEMIOLOGY Retrospective Studies Sensitivity and
Specificity Sputum/*MICROBIOLOGY Switzerland/EPIDEMIOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).